Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy.
Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy.
Expert Rev Med Devices. 2020 Jun 22;:
Authors: Fuchs J, Hovorka R
Abstract
INTRODUCTION: Type 1 diabetes is a lifelong disease with high management burden. The majority of people with type 1 diabetes fail to achieve glycaemic targets. Algorithm-driven automated insulin delivery (closed-loop) systems aim to address these challenges. This review provides an overview of commercial and emerging closed-loop systems.
AREAS COVERED: We review safety and efficacy of commercial and emerging hybrid closed-loop systems. A literature search was conducted and clinical trials using day-and-night closed-loop systems during free-living conditions were used to report on safety data. We comment on efficacy where robust randomised controlled trial data for a particular system are available. We highlight similarities and differences between commercial systems.
EXPERT OPINION: Study data shows that hybrid closed-loop systems are safe and effective, consistently improving glycaemic control when compared to standard therapy. While a fully closed-loop system with minimal burden remains the end-goal, these hybrid closed-loop systems have transformative potential in diabetes care.
PMID: 32569476 [PubMed - as supplied by publisher]
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
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