Ubiquitination of PPAR-gamma by pVHL inhibits ACLY expression and lipid metabolism, is implicated in tumor progression

Intracellular lipid accumulation is associated with various diseases, particularly cancer. Mitochondrial dysfunction is considered as a cause of lipid accumulation; however, the related underlying mechanism remains unclear.FindingsWe found that Von Hippel-Lindau (VHL)-deficiency led to lipid accumulation and mitochondrial dysfunction in renal cell carcinoma cells. Moreover, VHL downregulated ATP-citrate lyase (ACLY), a key enzyme in de novo lipid synthesis, at the transcriptional level, which inhibited intracellular lipid accumulation in human renal carcinoma tissues.

Source: Metabolism - Clinical and Experimental - June 22, 2020 Category: Biomedical Science Authors: Kyung Hee Noh, Hyun Mi Kang, Wonbeak Yoo, Yoohong Min, Daehun Kim, Mijin Kim, Sihyung Wang, Jung Hwa Lim, Cho-Rok Jung Source Type: research