POLE and POLD1 germline exonuclease domain pathogenic variants, a rare event in colorectal cancer from the Middle East

ConclusionPOLE andPOLD1 exonuclease domain pathogenic variants frequency in CRC cases was very low and these exonuclease domain pathogenic variants might be rare causative events of CRC in the Middle East.POLE andPOLD1 can be included in multi ‐gene panels to screen CRC patients.

Source: Molecular Genetics & Genomic Medicine - June 21, 2020 Category: Genetics & Stem Cells Authors: Abdul K. Siraj, Rong Bu, Kaleem Iqbal, Sandeep K. Parvathareddy, Tariq Masoodi, Nabil Siraj, Maha Al ‐Rasheed, Yan Kong, Saeeda O. Ahmed, Khadija A. S. Al‐Obaisi, Ingrid G. Victoria, Maham Arshad, Fouad Al‐Dayel, Alaa Abduljabbar, Luai Tags: ORIGINAL ARTICLE Source Type: research