The Renin-Angiotensin-Aldosterone System (RAAS) is One of the Effectors by Which Vascular Endothelial Growth Factor (VEGF)/anti-VEGF Controls the Endothelial Cell Barrier

Leakage of retinal blood vessels, which is an essential element of diabetic retinopathy (DR), is driven by chronic elevation of vascular endothelial growth factor (VEGF). VEGF quickly relaxes the endothelial cell barrier by triggering signaling events that post-translationally modify preexisting components of intercellular junctions. VEGF also changes expression of genes, which are known to regulate barrier function. This project ’s goal was to identify effectors by which VEGF and anti-VEGF control the endothelial cell barrier in cells that were chronically exposed to VEGF (hours instead of minutes).
Source: American Journal of Pathology - Category: Pathology Authors: Source Type: research