Antihypertensive effect of carvacrol is improved after incorporation in β-cyclodextrin as a drug delivery system.

Antihypertensive effect of carvacrol is improved after incorporation in β-cyclodextrin as a drug delivery system. Clin Exp Pharmacol Physiol. 2020 Jun 22;: Authors: Barreto L, Camargo SB, Dos Anjos Moraes R, Medeiros CF, de Melo Jesus A, Evangelista A, Villarreal CF, Quintans-Júnior LJ, Silva DF Abstract Carvacrol (CARV), has been shown to possess various pharmacological properties, especially in the treatment of cardiovascular diseases. We evaluated the antihypertensive effect of the CARV free and encapsulation of CARV in β-cyclodextrin (CARV/β-CD), and whether CARV/β-CD is able to improve the antihypertensive effects of CARV free in spontaneously hypertensive rats (SHR). The rats were randomly divided into 4 groups, each treated daily for 21 days and the mean arterial pressure and heart rate was measured every 5 days: group 1 (Wistar-vehicle solution); group 2 (SHR-vehicle); group 3 (SHR-CARV 50 mg/kg/day) and group 4 (CARV/β-CD 50 mg/kg/day). After 21 days of treatment, the mesenteric artery from treated animals was tested for phenylephrine (Phe) and sodium nitroprusside (SNP) sensitivity. In addition, administration of CARV/β-CD induced important antihypertensive activity when compared with the uncomplexed form, reducingthe progression of arterial hypertension in SHR. Moreover, pharmacological potency to Phe in the SHR-CARV and CARV/β-CD groups was increased, approaching values expressed in the wistar-vehicle. Furthermore...
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research