Berberine Administration in Treatment of Colitis: A Review.

Berberine Administration in Treatment of Colitis: A Review. Curr Drug Targets. 2020 Jun 21;: Authors: Ashrafizadeh M, Najafi M, Mohammadinejad R, Farkhondeh T, Samarghandia S Abstract Berberine (Brb) is one of the well-known naturally occurring compounds exclusively found in Berberis vulgaris and other members of this family such as Berberis aristata, Berberis aroatica, and Berberis aquifolium. This plant-derived natural compound has a variety of therapeutic impacts including anti-oxidant, anti-inflammatory, anti-diabetic and antitumor. Multiple studies have demonstrated that Brb has great anti-inflammatory activity and is capable of reducing the levels of pro-inflammatory cytokines, while it enhances the concentrations of anti-inflammatory cytokines making it suitable for the treatment of inflammatory disorders. Colitis is an inflammatory bowel disease with chronic nature. Several factors involve in the development of colitis and it appears that inflammation and oxidative stress are the most important ones. With respect to the anti-inflammatory and anti-oxidant effects of Brb, its administration seems to be beneficial in treatment of colitis. At the present review, we clarify the protective effects of Brb in colitis treatment and its impact on molecular pathways. PMID: 32564751 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research