Cancers, Vol. 12, Pages 1654: Prognostic Effect of Comorbid Disease and Immune Gene Expression on Mortality in Kidney Cancer —A Population Based Study

Cancers, Vol. 12, Pages 1654: Prognostic Effect of Comorbid Disease and Immune Gene Expression on Mortality in Kidney Cancer—A Population Based Study Cancers doi: 10.3390/cancers12061654 Authors: Chung-Shun Wong Tzu-Ting Chen Wei-Pin Chang Henry Sung-Ching Wong Mei-Yi Wu Wirawan Adikusuma Yuh-Feng Lin Wei-Chiao Chang The effect of comorbidities and the immune profiles of the kidney cancer microenvironment play a major role in patients’ prognosis and survival. Using the National Health Insurance Research Database (Taiwan), we identified patients aged >20 years with a first diagnosis of kidney cancer between 2005 and 2014. Differences in demographic characteristics and comorbidities were examined using the Pearson chi-squared test or the t test. The Cox regression model was used to construct the nomogram. RNA-seq data were applied from The Cancer Genome Atlas database, and correlations between immune metagenes and clinical characteristics were determined using a linear regression model. In this nationwide cohort study, including 5090 patients with kidney cancer, predictors in our prediction models included age, sex, chronic kidney disease, dialysis requirements, renal stones, cerebrovascular disease, and metastasis tumor. In the tumor tissue profiles, significant positive correlations between immune metagenes and clinical stage or overall survival were observed among Natural Killer (NK) cells (CD56−), CD4+ T-helper ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research