Diagnosing brain tumors with a blood test

(University Health Network) A simple but highly sensitive blood test has been found to accurately diagnose and classify different types of brain tumours, resulting in more accurate diagnosis, less invasive methods and better treatment planning in the future for the patients.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Roth P, Mason WP, Richardson PG, Weller M Abstract INTRODUCTION: Glioblastoma is a primary brain tumor with a poor prognosis despite multimodal therapy including surgery, radiotherapy and alkylating chemotherapy. Novel therapeutic options are therefore urgently needed; however, there have been various drug failures in late-stage clinical development. The proteasome represents a key target for anti-cancer therapy as successfully shown in multiple myeloma and other hematologic malignancies. AREAS COVERED: This review article summarizes the preclinical and clinical development of proteasome inhibitors in ...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Conditions:   Malignant Brain Neoplasm;   Recurrent Malignant Brain Neoplasm;   Refractory Malignant Brain Neoplasm Interventions:   Drug: Cyclophosphamide;   Drug: Fludarabine;   Biological: IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing Autologous T-Lymphocytes Sponsors:   City of Hope Medical Center;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aimed to investigate the effect of Piezo1 overexpression on peritumoral brain edema in glioblastomas. MATERIALS AND METHODS: The Piezo1 expression in cell lines and paired samples was detected by quantitative reverse transcription polymerase chain reaction, Western blot, and immunohistochemistry. Sixty-four patients with glioblastomas were analyzed retrospectively. The Piezo1 expression of tumor tissue was detected by immunohistochemistry. The diameters of tumor and edema were measured by preoperative MR imaging, and the edema index value was calculated. RESULTS: Western blot and quantitative reverse transcrip...
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: ADULT BRAIN Source Type: research
Abstract Fluorescent probes in the second near-infrared region (NIR-II, 1000~1700 nm) have resulted in unprecedented imaging performance. Here, we describe a fluorination strategy in semiconducting polymers for development of highly bright NIR-II probes. Notably, tetrafluorination yielded a fluorescence QY of 3.2% for the polymer dots (Pdots), over 3-fold enhancement as compared to non-fluorinated counterparts. The fluorescence enhancement was attributable to nanoscale fluorous effect in the Pdots that maintained the molecular planarity and minimized the structure distortion between the excited state and ground st...
Source: Angewandte Chemie - Category: Chemistry Authors: Tags: Angew Chem Int Ed Engl Source Type: research
In conclusion, our results confirm pr evious data that depression affects more than ¼ of patients with primary brain tumors, it is largely independent of tumor characteristics and is associated with shorter survival in patients with recurrent malignant gliomas. On PET imaging, higher tryptophan metabolism in the frontal cortex and thal amus was found in those with brain tumor-associated depression and supports the role of dysregulated tryptophan/kynurenine metabolism in this condition.
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
AbstractOncogenic gene fusions have been reported in diffuse gliomas and may serve as potential therapeutic targets. Here, using next-generation sequencing analysis (Illumina TruSight Tumor 170 panel), we analyzed a total of 356 diffuse gliomas collected from 2017 to 2019 to evaluate clinical, pathological, and genetic features of gene fusion. We found 53 cases of glioblastomas harboring the following oncogenic gene fusions:MET (n = 18),EGFR (n = 14),FGFR (n = 12),NTRK (n = 5),RET (n = 2),AKT3 (n = 1), andPDGFRA fusions (n = 1...
Source: Brain Tumor Pathology - Category: Neurology Source Type: research
AbstractIn recent times, researchers showed huge interest in machine learning approaches that attempts to develop the information representations via computational modules. Past decade gained momentum by deep learning approaches and their potential of enhancing the performance for numerous automation operations with superior future research applications. The novelties in medical image processing initialized the unique perspective to diagnose the human body with superior resolution and enhanced accuracy. This paper offers a comprehensive work on existing methodologies that attain optimum results in their respective domains....
Source: Health and Technology - Category: Information Technology Source Type: research
g-Luen Yu Glioblastoma is one of the most common and most aggressive brain cancers. The current treatment is mainly surgery, chemotherapy, and radiation therapy, but the results are not satisfactory. Ganoderma lucidum (G. lucidum), also called “Lingzhi”, is a medicinal mushroom that has been used as a therapeutic agent for the treatment of numerous diseases, including cancer. However, whether it is effective for treating cancer is still unclear. In the present study, the anti-tumor effect of a water extract of G. lucidum was investigated using brain tumor cells. We used an analysis of cell viability...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Treatment with topical minoxidil helps restore hair loss caused by radiation treatment for brain tumors and other head and neck cancers, a study published Wednesday by JAMA Dermatology found.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
In this study, we demonstrate a simple way to compare mass spectra obtained by different experimental protocols, assess its quality, and check for the presence of outliers and batch effect in the dataset. We compare the mass spectra of both fresh and frozen‐thawed astrocytic brain tumor samples obtained with the inline cartridge extraction prior to electrospray ionization. Our results reveal the importance of both positive and negative ion mode mass spectrometry for getting reliable information about sample diversity. We show that positive mode highlights the difference between protocols of mass sp ectra measurement, suc...
Source: Journal of Mass Spectrometry - Category: Chemistry Authors: Tags: SPECIAL ISSUE ‐ RESEARCH ARTICLE Source Type: research
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