Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire

Nature Reviews Clinical Oncology, Published online: 22 June 2020; doi:10.1038/s41571-020-0387-xImmune-checkpoint inhibition has transformed the treatment of patients with advanced-stage cancers. Nonetheless, the specific antigens targeted by T cells that are activated or reactivated by these agents remain largely unknown. In this Review, the authors describe the characterization and classification of tumour antigens including descriptions of the most appropriate detection methods, and discuss potential regulatory issues regarding the use of tumour antigen-based therapeutics.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research