Biodistribution studies of boronophenylalanine in different types of skin melanoma.

Biodistribution studies of boronophenylalanine in different types of skin melanoma.
Appl Radiat Isot. 2020 Sep;163:109215
Authors: Zhang Z, Yong Z, Jin C, Song Z, Zhu S, Liu T, Chen Y, Chong Y, Chen X, Zhou Y
Abstract
A study of the 10B-enriched Boronophenylalanine-fructose complex(10BPA-F) infusion procedure in potential BNCT patients, including three skin melanomas of extremities, was performed. 10B concentration in tumor(T), blood(B), skin(S) were measured to determine tumor/blood(T/B) and skin/blood(S/B) ratios. T/B ratio for three melanoma patients was in the range 1.48-3.82(average 2.56 ± 0.69). S/B ratio was in the range 0.81-1.99(average 1.29 ± 0.35). Results showed that T/B ratio of nodular metastasis melanoma was higher than superficial spreading melanoma. 10B concentration in skin was higher than blood, which was helpful to avoid over-dose in normal skin.
PMID: 32561053 [PubMed - as supplied by publisher]

Source: Applied Radiation and Isotopes - June 22, 2020 Category: Radiology Authors: Zhang Z, Yong Z, Jin C, Song Z, Zhu S, Liu T, Chen Y, Chong Y, Chen X, Zhou Y Tags: Appl Radiat Isot Source Type: research