Troponin T amino acid mutation ( ΔK210) knock-in mice as a neonatal dilated cardiomyopathy model.

CONCLUSIONS: TNNT2ΔK210/ΔK210 mice have already developed DCM at birth, indicating that they should be an excellent animal model to identify early progression factors of DCM. IMPACT: TNNT2ΔK210/ΔK210 mice are excellent animal model for DCM.TNNT2ΔK210/ΔK210 mice are excellent animal model to identify early progression factors of DCM.KEGG PATHWAY analysis revealed that several important pathways such as cancer and focal adhesion might be associated with the pathogenesis and development of neonatal DCM. PMID: 32563186 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research