Sarcoidosis simulating metastasis in patient with Merkel cell carcinoma

This article presents the case of a male patient, in the seventh decade of life, which had a prior MCC diagnosis and was subsequently diagnosed with sarcoidosis, which radiologically simulated lung and mediastinum metastasis. The association between MCC and sarcoidosis is infrequent and rarely described in literature, found in only two case reports.O carcinoma de células de Merkel (CCM) é um tumor neuroendócrino de pele, raro e agressivo, cuja etiologia permanece pouco compreendida. Disfunção do sistema imune é apontada como um possível fator causal, tanto para o CCM quanto para a sarcoidose. Este artigo descreve o caso de um paciente do sexo masculino, na sétima década de vida, com diagnóstico de CCM, posteriormente diagnosticado com sarcoidose, que, à radiologia, simulava metástase para pulmão e mediastino. A associação entre CCM e sarcoidose é rara e muito pouco descrita na literatura, encontrada em apenas dois relatos de casos.
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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In this study, we performed immunohistochemistry (IHC) assay. The results show that RASSF6 is upregulated in ESCC and that the elevated expression level of RASSF6 is associated with lymph node metastasis and poor survival of ESCC patients. Consistent with the clinical observations, the upregulation of RASSF6 greatly promotes ESCC cell proliferation, migration and invasion as well as the cell cycle transition to G1/S phase in vitro. According to models in vivo, the downregulation of RASSF6 considerably inhibits ESCC tumor growth and lung metastasis. Mechanistically, RASSF6 negatively regulates the tumor suppressor tripartit...
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type globally and contributes significantly to burden of disease in South Asia. In Pakistan, HNSCC is among the most commonly diagnosed cancer in males and females. The increasing regional burden of HNSCC along with a unique set of risk factors merited a deeper investigation of the disease at the genomic level. Whole exome sequencing of HNSCC samples and matched normal genomic DNA analysis (n=7) was performed. Significant somatic single nucleotide variants (SNVs) were identified and pathway analysis performed to determine frequently affe...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
ConclusionsA policy of selective histopathology after cholecystectomy is oncologically safe and reduces costs.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
This report discusses a case of Non-Hodgkin’s lymphoma in an 80-year male patient with clinical presentation of non-healing painless ulceroproliferative growth, which mimics squamous cell carcinoma.
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
Condition:   Renal Cell Carcinoma Intervention:   Drug: Fecal Microbiota Transplantation Sponsors:   Lawson Health Research Institute;   Academic Medical Organization of Southwestern Ontario Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Nasal Cavity and Paranasal Sinus Carcinoma;   Oral Cavity Carcinoma;   Pathologic Stage III HPV-Mediated (p16-Positive) Or opharyngeal Carcinoma AJCC v8;   Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8;   Recurrent Hypopharyngeal Carcinoma;   Recurrent Laryngeal Carcinoma;   Recurrent Nasal Cavity and Paranasal Sinus ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Lung Carcinoma Interventions:   Procedure: Biospecimen Collection;   Other: Laboratory Biomarker Analysis;   Procedure: Liquid Biopsy;   Other: Medical Chart Review Sponsors:   University of Southern California;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Hepatocellular Carcinoma Intervention:   Biological: allogeneic NK cells therapy Sponsors:   Beijing 302 Hospital;   Shenzhen Third People's Hospital;   The first People's Hospital of Zhengzhou Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Carcinoma, Small Cell;   Solid Tumors;   SCLC;   Extrapulmonary Lung Cancer;   Relapse Interventions:   Drug: Topotecan + M6620;   Drug: Topotecan Sponsor:   National Cancer Institute (NCI) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 14 November 2019Source: Seminars in Cancer BiologyAuthor(s): Tibor Tot, Maria Gere, Syster Hofmeyer, Annette Bauer, Ulrika PellasAbstractMany breast lesions are associated with microcalcifications that are detectable by mammography. In most cases, radiologists are able to distinguish calcifications usually associated with benign diseases from those associated with malignancy. In addition to their value in the early detection of breast carcinoma and accurate radiological diagnosis, the presence of microcalcifications often affects the extent of surgical intervention. Certain types of micro...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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