pH-dependent ileocolonic drug delivery, part II: preclinical evaluation of novel drugs and novel excipients.

pH-dependent ileocolonic drug delivery, part II: preclinical evaluation of novel drugs and novel excipients. Drug Discov Today. 2020 Jun 17;: Authors: Broesder A, Kosta AMAC, Woerdenbag HJ, Nguyen DN, Frijlink HW, Hinrichs WLJ Abstract Safety issues require that novel drugs and novel excipients, formulated in pH-dependent ileocolonic drug delivery systems, are tested in appropriate animal species before they are evaluated in humans. In a literature search, we found that, of the most frequently used laboratory animal species, the rabbit is the best choice. Its gastrointestinal (GI) pH values most resembles those in humans. In cases where rabbits cannot be used, pigs, dogs, and rats can serve as an alternative provided that GI pH values of individual animals are checked. Various methods to investigate the performance of ileocolonic drug delivery systems are available. We recommend testing novel drugs with non-invasive imaging techniques in combination with plasma sampling, whereas novel excipients are best tested with the theophylline-sulfasalazine method. PMID: 32562842 [PubMed - as supplied by publisher]
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Tags: Drug Discov Today Source Type: research