Application of medium-term metrics for assessing glucose homoeostasis: Usefulness, strengths and weaknesses.

Application of medium-term metrics for assessing glucose homoeostasis: Usefulness, strengths and weaknesses. Diabetes Metab. 2020 Jun 16;: Authors: Monnier L, Colette C, Owens D Abstract This review aims to address the issue of whether or not the newer metrics developed for continuous glucose monitoring [real-time CGM (rtCGM), intermittently scanned CGM (isCGM)] enhance assessment of the 'glucose tetrad': ambient hyperglycaemia, short-term glycaemic variability, postprandial glucose excursions and hypoglycaemia. The ever-increasing number of metrics offered with rtCGM and isCGM includes intermediate-term indicators referred to as 'time in range' (TIR), the time spent in the range of 70-180 mg/dL (TIR 70-180); time spent above the range of 180 mg/dL (TAR > 180); and time spent below the range of 70 mg/dL or 54 mg/dL (TBR < 70 or TBR < 54). The former two values are strongly correlated with HbA1c levels and can therefore serve as short- or medium-term markers of ambient hyperglycaemia, depending on whether glucose sensors are worn over periods of several days or weeks, respectively, whereas the latter indices (TBR < 70 or < 54) are more relevant for capturing hypoglycaemic events and quantifying their magnitude and duration, in contrast to random spot testing with self-monitoring of blood glucose. Nevertheless, although analyses of 24-h glucose profiles by CGM provide a highly valuable method for quantifying postprandial...
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research