XPC as breast cancer susceptibility gene: evidence from genetic profiling, statistical inferences and protein structural analysis.

CONCLUSION: In conclusion, both XPC polymorphisms confer significant association with increased BC risk. rs2228001 substitution may change the structural and functional preferences of XPC C-terminus, while rs2733532 may have regulatory role thereby leading to potential BC risk. PMID: 32562189 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32562189?dopt=Abstract

Source: Breast Cancer - June 18, 2020 Category: Cancer & Oncology Authors: Malik SS, Zia A, Rashid S, Mubarik S, Masood N, Hussain M, Yasmin A, Bano R Tags: Breast Cancer Source Type: research