Extracts and steroids from the edible mushroom Hypholoma lateritium exhibit anti-inflammatory properties by inhibition of COX-2 and activation of Nrf2.

Extracts and steroids from the edible mushroom Hypholoma lateritium exhibit anti-inflammatory properties by inhibition of COX-2 and activation of Nrf2. Chem Biodivers. 2020 Jun 19;: Authors: Vanyolos A, Muszyńska B, Chuluunbaatar B, Gdula-Argasińska J, Kała K, Hohmann J Abstract Hypholoma lateritium is an edible macrofungus with a common distribution in Europe, North America, and the Far East. The aim of this study was to investigate the potential anti-inflammatory effects of H. lateritium extracts and its isolated steroids: fasciculic acid B (1), fasciculol E (2), fasciculol C (3), lanosta-7,9(11)-diene-12β,21α-epoxy-2α,3β,24β,25-tetraol (4), fasciculol F (5), and demethylincisterol A2 ( 6 ). Organic ( n -hexane, chloroform and 50% methanol) and water extracts of H. lateritium were subjected to in vitro assays to determine pro-inflammatory protein levels, such as cyclooxygenase-2 (COX-2), cytosolic prostaglandin E2 synthase (cPGES), and antioxidant nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Fungal extracts demonstrated significant activities on pro-inflammatory protein levels with minor differences among the activities of the fractions of different polarities. Compounds (1-6 ) proved to exert notable inhibitory properties on COX-2 and were capable to stimulate the Nrf2 pathway. Fungal extracts and compounds (1-6 ) exerted no cytotoxic activities on RAW 264.7 cells. PMID: 32558141 [PubMed - as supplied by p...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research