Design of a cluster-randomized trial of the effectiveness and cost-effectiveness of metformin on prevention of type 2 diabetes among prediabetic Mexican adults (the PRuDENTE initiative of Mexico City)

We describe the design of a pragmatic trial to evaluate the incremental effectiveness of metformin, as an adjunct to a simple lifestyle counseling.

Source: Contemporary Clinical Trials - June 20, 2020 Category: Radiology Authors: Luis A. Rodr íguez, Simón Barquera, Carlos A. Aguilar-Salinas, Jaime Sepúlveda-Amor, Luz María Sánchez-Romero, Edgar Denova-Gutiérrez, Nydia Balderas, Lizbeth Moreno-Loaeza, Margaret A. Handley, Sanjay Basu, Oliva López-Arellano, Alberto Gallardo-H Source Type: research