Real-world data for pediatric medulloblastoma: can we improve outcomes?

Conclusion: Treatment delivery optimization has improved survival rates of patients with MB. Despite this, in our study, we have not established a clear influence of the considered radiotherapy and chemotherapy treatment quality parameters on outcomes.What is Known:• Improvement in treatment modalities during the last decades has reached a 5-year OS of up to 70% in these patients.• Extent of resection and radiotherapy parameters such as interval between surgery-radiotherapy and radiotherapy duration has been described as probable survival prognostic factors.What is New:• Differences in medulloblastoma survival rates between prospective studies and retrospective series.• The impact on survival of the three main treatment variables, surgery, radiotherapy and chemotherapy, susceptible to improvement.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research