Thrombin generation in children with sickle cell Anemia is Higher in the presence of platelets ⋆ and ⋆
Sickle cell disease (SCD) is a hemoglobin disorder leading to chronic hemolysis and multi-organ morbidity. Increasing evidence suggests that activation of coagulation contributes to its complications such as stroke, pulmonary hypertension, venous thromboembolism and avascular necrosis [1]. The effects are most profound in homozygous state Hemoglobin SS (HbSS) and Hemoglobin S-Beta zero thalassemia referred together as sickle cell anemia (SCA). With improved survival of patients with SCA in the current era, early recognition of long-term complications is a priority, but there is a paucity of biomarkers to identify SCA hypercoagulability.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Neethu Menon, Janna Journeycake, Rong Huang, Paul Riley, Ayesha Zia Source Type: research
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