Airway Epithelial Telomere Dysfunction Drives Remodeling Similar to Chronic Lung Allograft Dysfunction.

CONCLUSIONS: These findings demonstrate that telomere dysfunction isolated to airway epithelial cells leads to airway-centric lung remodeling and fibrosis similar to that observed in patients with CLAD and suggest that lung epithelial cell telomere dysfunction may be a molecular driver of CLAD.
PMID: 32551854 [PubMed - as supplied by publisher]

Source: Am J Respir Cell Mol... - June 17, 2020 Category: Respiratory Medicine Authors: Naikawadi RP, Green G, Jones KD, Achtar-Zadeh N, Mieleszko JE, Arnould I, Kukreja J, Greenland J, Wolters PJ Tags: Am J Respir Cell Mol Biol Source Type: research