ATF4 Mediates Mitochondrial Unfolded Protein Response (UPRmt) in Alveolar Epithelial Cells.

In conclusion, ER stress induces ATF4-dependent UPRmt and mitochondrial dysfunction, indicating a novel mechanism by which ER stress contributes to the pathogeneses of a variety of pulmonary disorders.
PMID: 32551949 [PubMed - as supplied by publisher]

Source: Am J Respir Cell Mol... - June 17, 2020 Category: Respiratory Medicine Authors: Jiang D, Cui H, Xie N, Banerjee S, Liu R, Dai H, Thannickal VJ, Liu G Tags: Am J Respir Cell Mol Biol Source Type: research