Lung clearance index-triggered intervention in children with cystic fibrosis – A randomised pilot study
Cystic fibrosis (CF) lung disease affects the small airways even early in life and is characterized by progressive, irreversible changes due to recurrent, multi-pathogenic infections and inflammation that may take place in absence of symptoms [1 –3]. In school-age children, CF lung disease is conventionally monitored by the forced expired volume in 1 s (FEV1) assessed by spirometry [4]. However, many children with CF and an abnormal lung clearance index (LCI) assessed by multiple breath inert gas washout (MBW) show a normal FEV1 [5].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Christian Voldby, Kent Green, Thomas Kongstad, Astrid Madsen Ring, Rikke Mulvad Sandvik, Marianne Skov, Frederik Buchvald, Tacjana Pressler, Kim Gjerum Nielsen Source Type: research