Association between PNPLA3 rs738409 G variant and MRI cerebrovascular disease biomarkers

Nonalcoholic fatty liver disease (NAFLD) has been associated with greater cerebral white matter hyperintensity (WMH) volume and microbleeds. The adiponutrin (PNPLA3) rs738409 G variant, a robust NAFLD susceptibility variant, has been variably associated with carotid atherosclerosis. We hypothesized that this variant is associated with WMH volume, microbleeds, covert brain infarction (CBI), and small perivascular spaces.

Source: Journal of the Neurological Sciences - June 18, 2020 Category: Neurology Authors: Neal S. Parikh, Nicole Dueker, Dalila Varela, Victor J. Del Brutto, Tatjana Rundek, Clinton B. Wright, Ralph L. Sacco, Mitchell S.V. Elkind, Jose Gutierrez Source Type: research