The impact of menopausal hormone therapy on overall mortality - a comprehensive review.
The impact of menopausal hormone therapy on overall mortality - a comprehensive review.
Climacteric. 2020 Jun 18;:1-13
Authors: Stute P, Stadler A, Heufelder A
Abstract
Menopausal hormone therapy (MHT) is indicated for menopausal symptom relief. However, MHT has also been shown to be beneficial for prevention of long-term estrogen deficiency sequelae including mortality. Based on a comprehensive literature review on MHT and mortality, the authors' recommendations are as follows: in postmenopausal women, MHT appears to confer a (significant) reduction in overall mortality; the benefit especially applies to women who initiate long-term MHT early after menopause; in women with prevalent cardiovascular risk factors (except for diabetes mellitus, where results are mixed), the benefit of MHT on overall mortality is even more pronounced; and, however, study results are difficult to compare due to heterogeneous study designs.
PMID: 32552066 [PubMed - as supplied by publisher]
Source: Climacteric - Category: Geriatrics Authors: Stute P, Stadler A, Heufelder A Tags: Climacteric Source Type: research
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