Magnesium Deficiency Causes Transcriptional Downregulation of Kir2.1 and Kv4.2 Channels in Cardiomyocytes Resulting in QT Interval Prolongation.

CONCLUSIONS: Intracellular Mg deficiency downregulates IK1and Itoin cardiomyocytes, and this is mediated by the transcription factors, NFAT and CREB. These results provide a novel mechanism for the long-term QT interval prolongation in hypomagnesemia. PMID: 32554946 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32554946?dopt=Abstract

Source: Circulation Journal - June 17, 2020 Category: Cardiology Authors: Shimaoka T, Wang Y, Morishima M, Miyamoto S, Ono K Tags: Circ J Source Type: research