Case report: exceptionally rapid growth character of hobnail variant of papillary thyroid carcinoma: a report of four cases.

Case report: exceptionally rapid growth character of hobnail variant of papillary thyroid carcinoma: a report of four cases. Endocr J. 2020 Jun 18;: Authors: Ito Y, Hirokawa M, Hayashi T, Ota H, Oshita M, Kihara M, Miya A, Miyauchi A Abstract The newest WHO classification adopts hobnail variant as an aggressive variant of papillary thyroid carcinoma (PTC). We here report four cases (ages 70-76 years, all females) with hobnail variant PTC treated at Kuma Hospital. Their lesions were cytologically diagnosed as PTC before surgery, but not as hobnail variant. All patients underwent a total thyroidectomy with central node dissection, and two patients also underwent therapeutic lateral node dissection. The clinical courses of three of the patients were very eventful. One patient showed recurrence to lymph nodes in the lateral compartment only 5 months after the initial surgery. In the initial surgery, one patient had a 36-mm lymph node metastasis in the lateral compartment, which was diagnosed as hobnail variant on pathology; 9 months post-surgery, metastases to the ipsilateral lateral lymph node, lung, and bone were newly detected. Her lung metastasis grew rapidly; its tumor volume-doubling time was 0.15 years and its tumor-doubling rate was 6.67/year. One patient underwent annual ultrasound examinations as postoperative follow-up after hemithyroidectomy for a benign nodule, but a 35-mm nodule diagnosed as PTC on cytology and lateral node...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research