Circulating extracellular vesicles as a noninvasive biomarker of rejection in heart transplant

: Circulating extracellular vesicles (EV) are raising considerable interest as a non-invasive diagnostic tool as they are easily detectable in biological fluids and contain specific set of nucleic acids, proteins, and lipids reflecting pathophysiological conditions. We aimed to investigate differences in plasma-derived EV surface-protein profile as biomarker to be used in combination with endomyocardial biopsies (EMB) for the diagnosis of allograft rejection.

Source: The Journal of Heart and Lung Transplantation - June 18, 2020 Category: Transplant Surgery Authors: C. Castellani, J. Burrello, M. Fedrigo, A. Burrello, S. Bolis, D. Di Silvestre, F. Tona, T. Bottio, V. Biemmi, G. Toscano, G. Gerosa, G. Thiene, C. Basso, S.L. Longnus, G. Vassalli, A. Angelini, L. Barile Source Type: research