Effect of soluble-viscous dietary fibre on coronary heart disease risk score across 3 population health categories: data from randomized, double-blind, placebo-controlled trials

Applied Physiology, Nutrition, and Metabolism, e-First Articles. We applied the Framingham risk equation in healthy, metabolic syndrome, and diabetes populations, following treatment with viscous fibre from konjac-based blend (KBB). KBB yielded reduction in estimated risk score by 16% (1.04 ± 0.03 vs. 0.87 ± 0.04, p< 0.01) in type 2 diabetes, 24% (1.08 ± 0.01 vs. 0.82 ± 0.02, p< 0.01) in metabolic syndrome, and 25% (1.09 ± 0.05 vs. 0.82 ± 0.06, p< 0.01) in healthy individuals. Drivers for decreased risk were improvements in blood cholesterol and systolic blood pressure. The composite coronary heart disease risk across populations was reduced 22% (p< 0.01). Novelty Viscous fibre from konjac-xanthan reduced 10-year relative coronary heart disease using Framingham Risk Score across the glycemic status spectrum.

Source: Applied Physiology, Nutrition, and Metabolism - March 25, 2020 Category: Physiology Authors: Vladimir Vuksan John L. Sievenpiper Elena Jovanovski Alexandra L. Jenkins Allison Komishon Fei Au-Yeung Andreea Zurbau Hoang V.T. Ho Dandan Li Lea Smircic-Duvnjak Source Type: research