MLLT10 in benign and malignant hematopoiesis

Each highly specified, functional member of the hematopoietic system is derived from a common progenitor: the hematopoietic stem cell (HSC) (reviewed in [1, 2]). HSCs have an indeterminate self-renewal capacity and give rise to progeny which become committed to the lymphoid or myeloid pathways, before terminally differentiating into functional members of the circulatory system [3-5]. This process is highly dependent on growth factors and transcription factors (TFs) which regulate gene expression patterns and facilitate these steps of commitment and differentiation [6-8].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Review Source Type: research