IL1B Increases Intestinal Tight Junction Permeability by Upregulation of MIR200C-3p, Which Degrades Occludin mRNA

Defects in the epithelial tight junction (TJ) barrier contribute to development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) increases intestinal permeability in mice. We investigated microRNAs that are regulated by IL1B and their effects on expression of TJ proteins and intestinal permeability.

Source: Gastroenterology - June 18, 2020 Category: Gastroenterology Authors: Manmeet Rawat, Meghali Nighot, Rana Al-Sadi, Yash Gupta, Dharmaprakash Viszwapriya, Gregory Yochum, Walter Koltun, Thomas Y. Ma Source Type: research