Liraglutide Effect on Ventricular Transient Outward K + Channel and Connexin-43 Protein Expression
Conclusions We have shown that pathological alterations in myocardial
Cx43 expression and distribution, in addition to reduced Ito
channel expression, may underlie the QTc interval prolongation in high-fat
diet/STZ rat model of type 2 diabetes mellitus. The beneficial
effects of Liraglutide, as those of Ramipril, on cardiac electrophysiology
could be at least attributed to its direct ability to normalize expression
and distribution of Cx43 and Ito channels in the diabetic rat
heart. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Ramadan, Nehal M. Malek, Hala Abdel Rahman, Karawan Abd-el El-Kholy, Elhamy Shaalan, Dalia Elkashef, Wagdi Tags: Article Source Type: research
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