Cancers, Vol. 12, Pages 1634: Oral Manifestations and Complications in Childhood Acute Myeloid Leukemia

Cancers, Vol. 12, Pages 1634: Oral Manifestations and Complications in Childhood Acute Myeloid Leukemia Cancers doi: 10.3390/cancers12061634 Authors: Francisco Cammarata‐Scalisi Katia Girardi Luisa Strocchio Pietro Merli Annelyse Garret Bernardin Angela Galeotti Fabio Magliarditi Alessandro Inserra Michele Callea Acute myeloid leukemia (AML) is a heterogeneous group of diseases, whose classification is based on lineage-commitment and genetics. Although rare in childhood, it is the most common type of acute leukemia in adults, accounting for 80% of all cases in this age group. The prognosis of this disease remains poor (especially in childhood, as compared to acute lymphoblastic leukemia); however, overall survival has significantly improved over the past 30 years. The health of the oral cavity is a remarkable reflection of the systemic status of an individual. Identification of the signs and symptoms of oral lesions can act as a warning sign of hidden and serious systemic involvement. Moreover, they may be the presenting feature of acute leukemia and provide important diagnostic indicators. Primary oral alterations are identified in up to 90% of cases of acute myeloid leukemia and consist of petechiae, spontaneous bleeding, mucosal ulceration, gingival enlargement with or without necrosis, infections, hemorrhagic bullae on the tongue, and cracked lips. Poor oral hygiene is a well-known risk factor for local and systemic infectious complications. Oro-...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research