Game Changer in Acne Treatment.

Game Changer in Acne Treatment. J Drugs Dermatol. 2020 Mar 01;19(3):28 Authors: Kircik LH Abstract Of the four primary pathogenic factors that drive acne vulgaris—androgen excess, increased sebum production, faulty keratinization, and overgrowth of C. acnes—androgen excess has been the most elusive therapeutic target. Oral contraceptive pills (OCPs) have direct effect on circulating hormones, but their potential use is limited to a subset of women. As such, a sizable portion of the population affected by acne vulgaris cannot even consider treatment with OCPs. While these systemic agents are generally associated with a low risk profile and have a history of safe and effective use, they are not entirely risk-free. Indirect androgen modulation through the use of spironolactone has become increasingly popular. PMID: 32550698 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32550698?dopt=Abstract

Source: Journal of Drugs in Dermatology - June 19, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research