Chemokines: the (un)usual suspects in pancreatic cancer neural invasion

Nature Reviews Gastroenterology & Hepatology, Published online: 19 June 2020; doi:10.1038/s41575-020-0329-1Pancreatic cancer is notorious for its affinity for invading nerves. A new study using a systematic unbiased RNA-interference screen of neuronal chemokines in cocultures of mouse sensory neurons and pancreatic cancer cells has now identified CCL21 and CXCL10 as key mediators of neural invasion, neural remodelling and pain in pancreatic cancer.
Source: Nature Reviews Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research