Signal Modeling and Simulation of Temporal Dispersion and Conduction Block in Motor Nerves

Conclusion: The simulation results closely match those of empirical measurements, indicating that the signal model captures relevant pathological mechanisms. An amplitude reduction of more than 50% in demyelinating conditions is in accordance with routine measurements and shows that temporal dispersion is quite well-modeled compared to previous simulation models. Significance: The simulation outcomes can serve as th- basis for an improved pathophysiological understanding of peripheral nerve disorders and should aid neurophysiologists to refine their diagnostic armamentarium resulting in a more precise differential diagnosis.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research