Huntington's disease: A new evidence of neurovascular dysfunction

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric abnormalities. The onset of the disease is usually in the third-fourth decade of life, however 5 –10% of subjects become symptomatic before 20 years (“juvenile Huntington's disease”). The disease is caused by an abnormal CAG repeat expansion in exon 1 of the “huntingtin” gene localized on the short arm of chromosome 4. This mutation leads to expression of the mutant huntingtin (mHtt ) protein which forms toxic intracellular aggregates that are ubiquitously found in the central nervous system and peripheral tissues [1].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research