Short-term effectiveness of biologics in patients with moderate-to-severe plaque psoriasis: a systematic review and network meta-analysis

Psoriasis is a chronic systemic inflammatory disorder characterized by persistent or repeating skin lesions [1]. Estimates suggest that more than 125 million people worldwide are affected by psoriasis [1], with the prevalence ranging from 2.7% in the USA to 8.7% in Norway [2]. The chronic activation of the innate and adaptive immune systems is involved in psoriatic disease manifestations, leading to increased release of pro-inflammatory cytokines, such as tumor necrosis factor- α (TNF-α), interleukin (IL)-17, IL-12, and IL-23 [1].

Source: Journal of Dermatological Science - June 17, 2020 Category: Dermatology Authors: Yayoi Tada, Rei Watanabe, Hisashi Noma, Yasumasa Kanai, Takanobu Nomura, Kenji Kaneko Source Type: research