Calcium sulfate ‐containing glass polyalkenoate cement for revision total knee arthroplasty fixation

We report here on novel modified g lass polyalkenoate cements (mGPCs) containing 1, 5 and 15 wt% calcium sulfate (CaSO4) and how the modified cements' properties compare to those of PMMA used in rTKA. CaSO4 is incorporated into the mGPC to improve both osteoconductivity and bioresorbability. The results confirm that the incorporation of CaSO4 into mGPCs decreases the setting time and increases release of therapeutic ions such as Ca2+ and Zn2+ over 30  days of maturation in deionized (DI) water. Moreover, the compressive strength for 5 and 15 wt% CaSO4 addition increased to over 30  MPa after 30 day maturation. Although the overall initial compressive strength of the mGPC (~ 30 MPa) is less than PMMA (~ 95 MPa), the compressive strength of mGPC is closer to that of cancellous bone (~ 1.2–7.8 MPa). CaSO4 addition did not affect biaxial flexural strength. Fourier transform infrared analysis indicated no cross ‐linking between CaSO4 and the GPC after 30  days. in vivo tests are required to determine the effects the modified GPCs as alternative on PMMA in rTKA.

Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - June 16, 2020 Category: Materials Science Authors: Leyla Hasandoost, Adel Alhalawani, Omar Rodriguez, Alireza Rahimnejad Yazdi, Paul Zalzal, Emil H. Schemitsch, Stephen D. Waldman, Marcello Papini, Mark R. Towler Tags: ORIGINAL RESEARCH REPORT Source Type: research