Butterfly Structure: A Privileged Scaffold Targeting Tubulin-Colchicine Binding Site.

Butterfly Structure: A Privileged Scaffold Targeting Tubulin-Colchicine Binding Site.
Curr Top Med Chem. 2020 Jun 16;:
Authors: Wang Y, Yao Y, Zhu HL, Duan Y
Abstract
Butterfly-shaped structure, as a novel scaffold with an attractive and certain shape, have been widely used in new drug discovery. Tubulin, composing of α- and β-tubulin heterodimers, plays a key role in mitosis and cell division which are regarded as an excellent target for cancer therapy. Currently, a series of butterfly shape diaryl heterocyclic compounds have been reported with strong potential against tubulincolchicine binding site. It have one ring buried in the β subunit, another ring interacts with the α subunit and the main body is located in the flat pocket. Here, we firstly introduce the concept of butterfly structure for the tubulin inhibitors, focus on the latest progress on a variety of molecules bearing butterfly structure and also illuminate the challenges and future direction of butterfly structure-based tubulincolchicine binding site inhibitors.
PMID: 32543362 [PubMed - as supplied by publisher]

Source: Current Topics in Medicinal Chemistry - June 15, 2020 Category: Chemistry Authors: Wang Y, Yao Y, Zhu HL, Duan Y Tags: Curr Top Med Chem Source Type: research