Effects of incretin agonists on endothelial nitric oxide synthase expression and nitric oxide synthesis in human coronary artery endothelial cells exposed to TNFα and glycated albumin.

CONCLUSIONS: TNFα and GA decrease production of NO in HCAEC, presumably by inducing reactive oxygen species or eNOS uncoupling. Incretin agonists in tested concentrations in the presence of l-arginine were not able to reverse this effect and instead led to a further reduction in NO production. PMID: 25560578 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25560578?dopt=Abstract

Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Garczorz W, Francuz T, Siemianowicz K, Kosowska A, Kłych A, Aghdam MR, Jagoda K Tags: Pharmacol Rep Source Type: research