Pioglitazone prevents morphine antinociceptive tolerance via ameliorating neuroinflammation in rat cerebral cortex.

CONCLUSION: It is concluded that oral administration of pioglitazone attenuates morphine-induced tolerance. This effect of pioglitazone may be, at least in part, due to its anti-inflammatory property which suppressed the cortical pro-inflammatory cytokine and inhibited of nuclear factor-kappa B activity. PMID: 25560579 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/25560579?dopt=Abstract

Source: Pharmacological Reports - January 11, 2015 Category: Drugs & Pharmacology Authors: Ghavimi H, Charkhpour M, Ghasemi S, Mesgari M, Hamishehkar H, Hassanzadeh K, Arami S, Hassanzadeh K Tags: Pharmacol Rep Source Type: research