Metformin and/or low dose radiation reduces cardiotoxicity and apoptosis induced by cyclophosphamide through SIRT-1/SOD and BAX/Bcl-2 pathways in rats.

Conclusions: The results revealed that MET and/or LDR attenuate CP-induced cardiotoxicity by inhibiting oxidative stress and preserving the activity of antioxidant enzymes through SIRT-1/SOD and BAX/Bcl-2 pathways. PMID: 32537703 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32537703?dopt=Abstract

Source: Molecular Biology Reports - June 13, 2020 Category: Molecular Biology Authors: El Kiki SM, Omran MM, Mansour HH, Hasan HF Tags: Mol Biol Rep Source Type: research