Samarium doped titanium dioxide nanoparticles as theranostic agents in radiation therapy

Metal-based nanoparticles (NPs) are being studied for their potential application as dose enhancing agents in radiation therapy, that is as radiosensitisers [1]. Upon interaction with radiations, the atoms of NPs can emit photoelectrons, Compton electrons, Auger electrons, and fluorescent X-rays via physical processes, such as photoelectric absorption of X-rays and the Compton effect [2]. These electrons and photons can generate reactive oxygen species (ROS) by radiolysis of water molecules, which causes more cellular damage and enhances the effects of radiations in cancer cells [3].
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Tags: Original paper Source Type: research