Gut barrier proteins mediate liver regulation by the effects of serotonin on the non-alcoholic fatty liver disease.

Gut barrier proteins mediate liver regulation by the effects of serotonin on the non-alcoholic fatty liver disease. Curr Protein Pept Sci. 2020 Jun 15;: Authors: Zhang K, Li X, Wang X, Zheng H, Tang S, Lu L, Ma X Abstract Serotonin (5-hydroxytryptamine, 5-HT) has been recognized as a potent pro-inflammatory mediator. Increasing the bioavailability and preventing the formation of 5-HT can reduce the inflammatory response in the body. Moreover, 5-HT is considered as an important central physiologic mediator of intestinal function by regulating intestinal motility, permeability and other functions. The dysfunction of intestinal serotonergic system causes intestinal barrier damage and it further leads to the increase of bacterial endotoxin (LPS) translocation into the liver which contributes to the development of non-alcoholic fatty liver disease (NAFLD). In addition, increasing the expression of serotonin reuptake transporter (SERT) and decreasing the expression of tryptophan hydroxylase1 (TPH1) can relieve the symptoms of NAFLD. Tryptophan (TRP) as a precursor of 5-HT synthesis plays an important role in gut homeostasis and energy metabolism. Previous studies have found that TRP supplementation aggravates fatty liver degeneration by producing 5-HT which activates mTOR signaling pathway in mice fed a high fat and high fructose diet. However, recent researches reveals that TRP supplementation stabilizes the intestinal barrier damage by i...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research