Inflammatory Bowel Disease in Children with Systemic Juvenile Idiopathic Arthritis.

CONCLUSION: IBD in the setting of sJIA is a rare occurrence. The favorable response of sJIA symptoms to therapeutic TNF-α inhibition suggests that the sJIA-IBD cohort may represent a mechanistically distinct sJIA subgroup. Our study highlights the importance of maintaining a high level of suspicion for IBD when gastrointestinal involvement occurs in sJIA patients and the likely broad benefit of TNF-α inhibition in those cases.
PMID: 32541073 [PubMed - as supplied by publisher]

Source: J Rheumatol - June 14, 2020 Category: Rheumatology Authors: Maller J, Fox E, Park KT, Paul SS, Baszis K, Borocco C, Prahalad S, Quartier P, Reinhardt A, Schonenberg-Meinema D, Shipman L, Terreri MT, Simard J, Lavi I, Chalom E, Hsu J, Zisman D, Mellins ED, CARRA Legacy Registry Investigators Tags: J Rheumatol Source Type: research