Guanidyl modification of the 1-azabicyclo[3.1.0]hexane ring in ficellomycin essential for its biological activity

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00339E, PaperSumire Kurosawa, Kenichi Matsuda, Fumihito Hasebe, Taro Shiraishi, Kazuo Shin-ya, Tomohisa Kuzuyama, Makoto Nishiyama The 1-Azabicyclo[3.1.0]hexane ring is a key moiety in the natural products for biological activities against bacteria, fungi, and tumor through DNA alkylation. Ficellomycin is a dipeptide that consists ofL-valine... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research