The Lancet Infectious Diseases: Study from Chinese city of Guangzhou provides key insights on how COVID-19 spreads in households

(The Lancet) New modelling research, published in The Lancet Infectious Diseases journal, suggests the coronavirus (SARS-CoV-2) that causes COVID-19 may spread more easily among people living together and family members than severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS). The estimates are the first of their kind to quantify symptomless transmission.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

Related Links:

CONCLUSIONS: This translational diagnostic tool will assist emergency and primary care clinicians, as well as out-of-hospital providers, in effectively managing people with suspected or confirmed SARS-CoV-2. PMID: 32633414 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Compared with Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible....
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research article Source Type: research
AbstractPurpose of reviewWithin the last two decades several members of the Coronaviridae family namely Severe Respiratory Syndrome (SARS-CoV) and Middle East Respiratory Syndrome (MERS-CoV) have demonstrated epidemic potential. In late, 2019 an unnamed genetic relative, later named SARS-CoV-2 realized its potential in the highly populous neighborhoods of Wuhan, China. Unchecked, the virus rapidly spread among interconnected communities and related households before containment measures could be in acted. “Appropriate” diagnostic testing in response to the SARS-CoV-2 outbreak should be urgently considered. This...
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has prompted the repurposing of drugs on the basis of promising in vitro and therapeutic results with other human coronavirus diseases such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). These repurposed drugs have mainly included remdesivir, favipiravir, lopinavir/ritonavir, ribavirin, interferons, and hydroxychloroquine. Unfortunately, the first open-label, randomized controlled trials are showing the poor efficacy of these repurposed drugs. Th...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
AbstractAfter the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in the last two decades, the world is facing its new challenge in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic with unprecedented global response. With the expanding domain of presentations in COVID-19 patients, the full range of manifestations is yet to unfold. The classical clinical symptoms for SARS-CoV-2 affected patients are dry cough, high fever, dyspnoea, lethal pneumonia whereas many patients have also been found to be associated with a few addi...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel zoonotic pathogen. It is responsible for Coronavirus Disease 2019 (COVID-19) [1]. The COVID-19 pandemic has imposed a heavy burden on global health and medical systems [2]. A whole genome scan has shown that SARS-CoV-2 has a 79% similarity to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), and a 50% similarity to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [3]. Currently, SARS-CoV-2 is classified as a SARS-associated coronavirus and taxonomically belongs to the subgenus of Sabek virus [3].
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
CONCLUSION: Nigella sativa has potent anti-SARS-CoV activity and it might be useful souce for developing novel antiviral therapies for coronaviruses. PMID: 32619167 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 coronavirus. Our literature and clinical trial survey showed that the whole virus, as well as the spike (S) protein, nucleocapsid (N) protein, and membrane (M) protein, have been tested for vaccine development against SARS and MERS. However, these vaccine candidates might lack the induction of complete protection and have safety concerns. We then applied the Vaxign and the newly developed machine learning-based Vaxign-ML reverse vaccinology tools to pred...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Non-canonical nucleic acid structures play important roles in the regulation of molecular processes. Considering the importance of the ongoing coronavirus crisis, we decided to evaluate genomes of all coronaviruses sequenced to date (stated more broadly, the order Nidovirales) to determine if they contain non-canonical nucleic acid structures. We discovered much evidence of putative G-quadruplex sites and even much more of inverted repeats (IRs) loci, which in fact are ubiquitous along the whole genomic sequence and indicate a possible mechanism for genomic RNA packaging. The most notable enrichment of IRs was found inside...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Viral infections are known to impact coronary disease, and acute myocardial infarction (AMI) may be triggered by the inflammatory cytokine response to infection.1,2 Cytokines promote local inflammation in atherosclerotic plaques within the coronary artery, which can lead to plaque destabilization, rupture, and eventually AMI development. Psychological adversity, depression, stress at home or work, social isolation and loneliness are also known factors contributing to acute vascular event.3 Recent outbreaks of coronavirus (CoV), including severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS) ...
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
More News: China Health | Coronavirus | COVID-19 | Infectious Diseases | International Medicine & Public Health | MERS | Middle East Health | Respiratory Medicine | SARS | Science | Study