Artemisinin attenuates IgM xenoantibody production via inhibition of T cell-independent marginal zone B cell proliferation.

In this study, we demonstrate that ART decreases T cell-independent xenogeneic IgM Ab production and, this is associated with a strong suppression of MZ B cell proliferation and a relative increase of CD21low CD23+ follicular and B10 B cells. In addition, this suppression impairs IL-10 production. Taken together, our data indicate that ART suppresses B cell immune responses through a distinctive effect on splenic MZ B and other B cells. This represents a new mechanism of ART-induced immunosuppression.
PMID: 32542769 [PubMed - as supplied by publisher]

Source: Journal of Leukocyte Biology - June 14, 2020 Category: Hematology Authors: Liu L, Zhao J, Li A, Yang X, Sprangers B, Li S Tags: J Leukoc Biol Source Type: research