Influence of Cow ’s Milk and Esomeprazole on the Absorption of Erlotinib: A Randomized, Crossover Pharmacokinetic Study in Lung Cancer Patients

ConclusionMilk with 3.9% fat has no effect on the exposure to erlotinib in NSCLC patients, independent of PPI use. The combination with milk is safe and well tolerated. Concomitant esomeprazole treatment strongly decreased both erlotinib AUC24 andCmax and should be avoided if possible.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research