2. Large structural variations in inflammatory breast cancer identifies possible pathognomonic alterations

Inflammatory breast cancer (IBC) is a clinical diagnosis that spans all breast cancer clinical and molecular subtypes. The clinical course of IBC is associated with poorer outcomes than molecular subtype-matched non-IBC and represents an unmet need in breast cancer therapy. IBC is characterized by invasive dermal lymphatic tumor emboli resulting in erythema and edema of the breast. These features suggest a pathognomonic common molecular theme or alteration, which if identified and targeted, could help reduce the mortality related to this highly aggressive breast cancer type.

Source: Cancer Genetics and Cytogenetics - May 31, 2020 Category: Genetics & Stem Cells Authors: Justin Balko, Ann Hanna, Paula Gonzalez-Ericsson, Abigail Toren, Susan Opalenik, Melinda Sanders Source Type: research